학술 및 논문 자료 7

1. Author(year): Van Vark et al. (2017)

2. Study: TRIUMPH

3. Population: Hospitalized for acute HF

4. Study description: Prognostic value of baseline and repeated ST2 measurements in patients with acute HF

5. N: 496

6. Average age(year): 74

7. Average LVEF(%): 30

8. Primary outcome:  All-cause mortality and readmission for HF

9. Follow-up duration: 1 year

10. Summary of findings: The repeated measurements of ST2 are a strong and independent predictor of adverse outcome in patients following admission for acute HF. The repeated ST2 measurements identified patients at a substantially higher risk of adverse events than did baseline ST2 levels alone. In addition, repeated ST2 measurements offer incremental prognostic value to that conferred by other known risk factors and , importantly, repeated measurements of NT-proBNP.

11. Link: https://www.jacc.org/doi/pdf/10.1016/j.jacc.2017.09.026

1. Author(year): Demissei et al. (2016)

2. Study: RELAX-AHF

3. Population:  

4. Study description:  Prognostic value of multi-time point-based multimarker panel of biomarkers in patients with acute heart failure

5. N: 1161

6. Average age(year): 72±11.2

7. Average LVEF(%): 45.2% ≥40%

8. Primary outcome: Cardiovascular mortality with 180 days

9. Follow-up duration: 180 days

10. Summary of findings:  

A combination of biomarkers reflecting diverse pathophysiological pathways provides significant prognostic improvement on top of readily available clinical and laboratory parameters unmatched by any single biomarker. Multimarker models are highly accurate and objective risk stratification tools that can play a crucial role in the development of need-based, personalized treatment strategies in AHF.

11. Link: https://onlinelibrary.wiley.com/doi/pdf/10.1002/ejhf.749

1. Author(year): Mebazza et al. (2015)

2. Study: 

3. Population: Hospitalized for ADHF 

4. Study description:  ST2 and multimarker testing in ADHF

5. N: 

6. Average age(year): 

7. Average LVEF(%): 

8. Primary outcome: 

9. Follow-up duration: 

10. Summary of findings:  

Kaplan-Meier confirmed a twofold increased risk of death in patients with ADHF with elevated plasma levels of ST2 or CRP and fourfold increased risk if both CRP and ST2 were elevated.

11. Link: https://core.ac.uk/download/pdf/74320174.pdf

1. Author(year): Lassus et al.

2. Study: MOCA

3. Population: Patients hospitalized for ADHF

4. Study description:  The Multinational Observational Cohort on Acute Heart Failure (MOCA) study

5. N: 5306

6. Average age(year): 75

7. Average LVEF(%): 40

8. Primary outcome: Death

9. Follow-up duration: 1 years

10. Summary of findings:  

Novel biomarkers such as sST2 and MR-proADM detect features of risk not identified by conventional risk markers and improve risk prediction models of both short-term(30-day) and one-year mortality in ADHF.

11. Link: https://biochemmack.ru/upload/iblock/7b7/7b75eee511f106ccd364490fe73bc0c7.pdf

1. Author(year): Manzano Fernandez et al. (2012)

2. Study: Murcia, Spain

3. Population: Hospitalized ADHF

4. Study description:  Serial ST2, measured on presentation and on day 4

5. N: 72

6. Average age(year): 69

7. Average LVEF(%): 47

8. Primary outcome: Death

9. Follow-up duration: 2 years

10. Summary of findings:  ST2 levels at both time points were prognostic, and decreased over time; serial levels improved c-statistic.

11. Link: https://www.researchgate.net/profile/Miguel-Boronat/publication/230568090_Serial_Monitoring_of_Soluble_Interleukin_Family_Member_ST2_in_Patients_with_Acutely_Decompensated_Heart_Failure/links/58d18f9aa6fdcc3fe7852602/Serial-Monitoring-of-Soluble-Interleukin-Family-Member-ST2-in-Patients-with-Acutely-Decompensated-Heart-Failure.pdf

 

1. Author(year): Pascual-Figal et al.

2. Study: Marcia, Spain

3. Population: Hospitalized ADHF

4. Study description: ST2, hsTnT, NT-proBNP assessed number of elevated markers(0-3)

5. N: 107

6. Average age(year): 72

7. Average LVEF(%): 47

8. Primary outcome: Death

9. Follow-up duration: 2 years

10. Summary of findings: ST2 levels predicted risk alone and as part of multimarker score.

11. Link: https://onlinelibrary.wiley.com/doi/epdf/10.1093/eurjhf/hfr047

1. Author(year): Boisot et al. (2008)

2. Study: VASDHS

3. Population: Hospitalized ADHF

4. Study description: Serial ST2, BNP and NT-proBNP levels; percentage change calculated from admission to D/C

5. N: 150

6. Average age(year): >65

7. Average LVEF(%): N/A

8. Primary outcome: Death

9. Follow-up duration: 90 days

10. Summary of findings: Percentage change in ST2 predicted outcomes independent of NPs; ST2 failure to decrease 15% predicted increased risk.

11. Link: https://www.biochemmack.ru/upload/iblock/d17/d17d21ba3fbdff9c8b39e7806822267a.pdf